Press note about TDMQ

A little late update, but at the end of last year a press note was published by our Institute highlighting Magda’s work on the electrochemical properties of TDMQ20, a molecule that has been proposed as a potential drug for treatment of Alzheimer’s disease. The press note concerns the two papers¹² on TDMQ20 that we published in the journal Bioelectrochemistry. These papers were in collaboration with Martin Perez-Estebanez from Alvaro Colina’s group in Burgos in Spain. The Polish-Spanish collaboration is illustrated by the flags in the picture above.

The collaboration will continue, as Magda is travelling again to Burgos for further experiments. These kinds of collaborations are extremely important, because, as pointed out in the press note³:

The demonstrated work shows how combining expertise from different fields, such as electrochemistry, spectroscopy, and computational modelling, enables insights that none of these fields could achieve alone. Secondly, they demonstrate that spectroelectrochemistry is a powerful tool, providing support in understanding how drug candidates behave under physiologically relevant redox conditions. Their studies emphasize the combining two techniques within a single experiment. This integrated spectroelectrochemical approach makes it possible to obtain much broader information about structural changes under redox reactions. Exploring the oxidation and reduction potentials of biologically active molecules provides information directly connected to their activity inside the body. Yet, such an approach is still rarely applied in drug-related studies.

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1. M. Z. Wiloch, M. Perez-Estebanez, N. Baran, A. Heras, M. Jönsson-Niedziółka, A. Colina
   Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer’s disease, Bioelectrochem 161, 108814 (2025). (link – OA)(blog)
2. M. Perez-Estebanez, F. Olmo-Alonso, N. Baran, M. Jönsson-Niedziółka, M. Wiloch
   Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer’s disease – Part 2 – Cu-complexes, Bioelectrochem. 168, 109115 (2026). (link – OA)(Preprint on ChemRxiv)(blog)
3. Text by Dr Magdalena Osiał