Polish title: Przyłóżkowy czujnik oparty na peptydach do wykrywania biomarkerów chorób neurodegeneracyjnych
Funding source: National Science Centre Poland (NCN)
Project number: 2024/53/B/ST4/03737
PI: Martin Jönsson-Niedziółka
Total funding: 2 608 360 PLN
Timeframe: 2025-10-01 – 2029-09-30
Short description
The scientific goal of this project is to push the limits of detection for point-of-care sensors by using an electrowetting-based system for sample mixing to enhance receptor-analyte binding kinetics and phage display technology to isolate high-affinity peptide-based receptors. The result will be a point-of-care testing sensor for measurements directly in whole blood of biomarkers of neurodegenerative diseases based on peptide recognition elements.
Point-of-care testing (POCT) is expected to play an ever-larger role in modern healthcare delivery, offering rapid and convenient diagnostic solutions at or near the patient’s location. The primary advantage of POCT is that it can provide real-time diagnosis, enabling healthcare providers to make immediate treatment decisions and improve patient outcomes.
The project is divided into two main parts: an electrochemical part, where efforts are focused on addressing the factors that are limiting the function of POCT sensors; and a molecular biology part, where the phage display technique will be used to identify peptides with high affinity towards a particular biomarker. The project is a collaboration with Dr Katarzyna Szot-Karpińska, who specialises in the use of phage display for peptide identification.
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