β-amyloids

7 posts
Publications

Investigation of copper binding competition between a potential anti-Alzheimer’s drug and Aβ(1–16) based on voltametric and chemometric analysis

Within her SONATINA grant, Magda is conducting research on a new potential therapeutic molecule: TDMQ20. In our previous posts, we described her electrochemical studies, which helped better understand the redox properties of TDMQ20 itself and its complexes with copper ions (Cu(II)). The next stage of the project focused on investigating the extent […]

Publications

Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer’s disease

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Collaboration is extremely important to us. Gaining new knowledge, both practical and theoretical, is also extremely important. For this reason, Magda went on a 6-month internship to Professor Alvaro Colina’s group in Burgos, Spain. The cooperation turned out to be very successful because shortly after her return our first article […]

Publications

Redox behaviour of Cu-Aβ(4-16) complexes related to Alzheimer’s Disease

The next paper in Magda’s series of articles on the redox behaviour of β-amyloids relevant for Alzheimer’s disease has just hit the press. Here we have been looking at how the presence of a redox-active amino acid, tyrosine (Tyr), affects the oxidation of a Cu(II) attached to the amino terminus […]

Publications

Very small changes in the peptide sequence alter the redox properties of Aβ(11-16)-Cu(II) and pAβ(11-16)-Cu(II) β-amyloid complexes

Sometimes publishing doesn’t go according to plan…. Our newly published article in J. Electroanal. Chem. was supposed to have been published before the follow-up in ChemElectroChem. We thought it made sense to first study the shorter amyloid and then follow with a study of the longer one. Some review delays […]

Publications

The Influence of Coordination Mode on the Redox Properties of Copper Complexes with Aβ(3-16) and its Pyroglutamate Counterpart pAβ(3-16)

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Over the last year, Magda has been working with bachelor student Natalia to investigate the redox behaviour of different β-amyloids. In her recently published paper she demonstrates a significant difference in the redox behaviour of copper complexes with peptides associated with Alzheimer’s disease (AD). AD is a neurodegenerative disorder and […]