Polish title: Elektrochemia Choroby Alzheimera – badania woltamperometryczne nowo odkrytych β-amyloidów
Funding source: Polish National Science Centre (NCN)
PI: Magdalena Zofia Wiloch
Total funding: 48 400.00 PLN
The project concerns research focused on a selected group of N-terminal β-amyloids, which differ significantly in the way of coordinating copper (II) ions. What are β-amyloids? According to one of the most popular theories they are peptides responsible for the development of Alzheimer’s disease. Although β-amyloids are a widely studied group of compounds, it is still not fully known how changes in the structure of these peptides influence into redox reactions taking place in the brain affected by the Alzheimer’s disease. In this project, special attention will be paid to those β-amyloids whose amino acid sequence begins with glutamic acid. The conversion of glutamic acid to pyroglutamic acid, carried out by the enzyme found in the cerebrospinal fluid, results in significant changes in the coordination of copper (II) cations. The research will help to determine what type of reactions may or may not occur in the brains affected by Alzheimer’s disease.
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